December 2021

28 Articles

No Section

The coupling between sarcopenia and COVID-19 is the real problem

22 September 2021
Author(s): Rizwan Qaisar, Asima Karim, Tahir Muhammad, Islam Shah, M. Shahid Iqbal

Dear Editor

Sarcopenic obesity is the real problem in COVID-19 !

15 August 2021
Author(s): Murat Kara, Ayşe Merve Ata, Levent Özçakar

Dear Editor,

Multimodal rheumatologic complex treatment in patients with spondyloarthritis - a prospective study

2 August 2021
Author(s): Philipp Klemm, Paulina Preusler, Ole Hudowenz, Thomas Asendorf, Ulf Müller-Ladner, Elena Neumann, Uwe Lange, Ingo H. Tarner

The spondyloarthritides (SpA) are a group of related diseases comprising axial SpA (axSpA), namely non-radiographic (nr-axSpA) and radiographic axSpA (r-axSpA), psoriatic arthritis (PsA), arthritis/... more

Future directions in obesity pharmacotherapy

20 May 2021
Author(s): Nick Finer

Treatment of obesity remains problematic. Compared to other chronic diseases such as hypertension and type 2 diabetes, there are few pharmacological options for treating obesity: thus the treatment... more


Personalized and tailored management of obesity at individual target brings success

13 October 2021
Author(s): Gabriele Perriello

Over the last decades, obesity has nearly tripled worldwide [1]. The current spread of obesity across sub-Saharan Africa and southeast Asia will end up with this condition becoming a global epidemic... more

KDIGO guidelines for the management of blood pressure in chronic kidney disease: A sprint to the curve

29 September 2021
Author(s): Nicolás Roberto Robles, Juan Villa, Francesco Fici

The KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease has been recently released [1]. The guidelines suggest (but do not recommend) that adults... more

18F-FDG PET-CT versus contrast enhanced CT for the diagnosis of fever of unknown origin

27 September 2021
Author(s): Nicolò Pipitone, Massimiliano Casali, Carlo Salvarani

Fever of unknown origin (FUO), also known as pyrexia of unknown origin, is commonly defined according to the Petersdorf criteria as fever ≥38.3° (101 Fahrenheit) lasting ≥3 weeks that remains... more

The importance of non-pharmacological treatment in spondyloarthritis

7 September 2021
Author(s): Ana Sofia Alves, Fernando Salvador

Spondyloarthritis (SpA) is a related group of inflammatory joint diseases comprising axial SpA (axSpA), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel disease, reactive... more

Internal Medicine Flashcard

An unusual cause of heart failure

11 September 2021
Author(s): Perryn Ng, Edgar Tay

A 59 year-old lady presents to the hospital with complaints of exertional shortness of breath for the past few months. This was associated with orthopnea and lower limb swelling. On examination, she... more

Subarachnoid hemorrhage as the key to the diagnosis

6 September 2021
Author(s): Miguel Miranda, Vera Montes, Sandra Sousa

A 70-year-old woman was admitted at the emergency department due to abdominal pain progressing over the last six hours. She had been feeling sick for the last month, with nausea and persistent fever... more

The truth comes out of children's mouths

6 September 2021
Author(s): Bénédicte Decoudier, Yohan N'Guyen

A 16 year-old patient of Hawaiian ancestry was admitted for confusion in April 2018. He had no relevant past medical history except he went to the dentist few months ago for patchy darkish pigmented... more

Skin lesions, weakness, and axillary adenopathies in a 44-year-old woman

3 September 2021
Author(s): José Antonio Rueda-Camino, Ignacio Robles-Barrena, María Carmen Vegas-Sánchez

A 44-year-old woman was referred to the Internal Medicine clinic with a six months history of generalized, worsening myalgia, Raynaud's phenomenon and muscular weakness. These symptoms were... more

Letter to the Editor

Serum IgG4 level predicts COVID-19 related mortality

23 September 2021
Author(s): Emanuel Della-Torre, Marco Lanzillotta, Marta Strollo, Giuseppe Alvise Ramirez, Lorenzo Dagna, Moreno Tresoldi, COVID-BioB study group

Dear Editor,

Beyond atrial fibrillation detection: how digital tools impact the care of patients with atrial fibrillation

13 September 2021
Author(s): Yutao Guo, Gregory Y.H. Lip

The modern treatment approach to AF has evolved with the identification of frequency and duration of AF episodes. Current guidelines recommend the 4S-AF approach to AF characterization and evaluation... more

Vitamin D deficiency and inactivated SARS-CoV-2 vaccines

8 September 2021
Author(s): Chia-Chao Wu, Kuo-Cheng Lu

Vaccines are a critical tool in the battle against COVID-19. An amazing article regarding the effects of 2 inactivated SARS-CoV-2 vaccines in symptomatic COVID-19 patients, and stated that the... more

Atrial high rate episodes as a marker of atrial cardiomyopathy: In the quest of the Holy Grail

17 August 2021
Author(s): Ioannis Doundoulakis, Dimitris Tsiachris, Konstantinos A Gatzoulis, Christodoulos Stefanadis, Konstantinos Tsioufis

Cardiac Implantable Electronic Devices (CIEDs) with atrial lead implanted allow detection of asymptomatic atrial tachy-arrhythmias defined as Atrial High Rate Episodes (AHRE) which are found in... more

ChAdOx1 nCoV-19 effectiveness during an unprecedented surge in SARS COV-2 infections

15 August 2021
Author(s): Ruma Satwik, Ambarish Satwik, Satendra Katoch, Satish Saluja


Original Article

The yield of F18 FDG PET-CT for the investigation of fever of unknown origin, compared with diagnostic CT

20 August 2021
Author(s): S. Buchrits, A. Gafter-Gvili, Y. Eynath, H. Bernstine, D. Guz, T. Avni

Fever of unknown origin (FUO) is a challenging diagnostic condition. The differential diagnosis of FUO includes a broad spectrum of highly diverse diseases which are mainly subdivided into four... more

Tocilizumab for the treatment of immune-related adverse events: a systematic literature review and a multicentre case series

12 August 2021
Author(s): Corrado Campochiaro, Nicola Farina, Alessandro Tomelleri, Roberto Ferrara, Chiara Lazzari, Giacomo De Luca, Alessandra Bulotta, Diego Signorelli, Anna Palmisano, Davide Vignale, Giovanni Peretto, Simone Sala, Antonio Esposito, Marina Garassino, Vanesa Gregorc, Lorenzo Dagna

Immune checkpoint inhibitors (ICI) have been a major breakthrough in the treatment scenario of patients affected by solid cancers and haematological malignancies. First-line pembrolizumab, a... more

Impact of implementing a Choosing Wisely educational intervention into clinical practice: The CW-SIMI study (a multicenter-controlled study)

2 August 2021
Author(s): Giorgio Costantino, Ludovico Furlan, Christian Bracco, Maria Domenica Cappellini, Giovanni Casazza, Vanessa Nunziata, Chiara Beatrice Cogliati, Anna Fracanzani, Raffaello Furlan, Giovanni Gambassi, Roberto Manetti, Raffaele Manna, Alfonso Piccoli, Alberto Moggi Pignone, GianMarco Podda, Teresa Salvatore, Stefania Sella, Alessandro Squizzato, Moreno Tresoldi, Francesco Perticone, Antonello Pietrangelo, Gino Roberto Corazza, Nicola Montano

In 2012, the American Board of Internal Medicine launched the Choosing Wisely (CW) campaign [1] with the purpose of reducing inappropriate and harmful procedures in clinical practice. The CW campaign... more

Identification of chronic thromboembolic pulmonary hypertension on CTPAs performed for diagnosing acute pulmonary embolism depending on level of expertise

20 July 2021
Author(s): Gudula J.A.M. Boon, Pushpa M. Jairam, Gerie M.C. Groot, Cornelis J. van Rooden, Yvonne M. Ende-Verhaar, Ludo F.M. Beenen, Lucia J.M. Kroft, Harm Jan Bogaard, Menno V. Huisman, Petr Symersky, Anton Vonk Noordegraaf, Lilian J. Meijboom, Frederikus A. Klok

Chronic thromboembolic pulmonary hypertension (CTEPH) is the only potentially curable form of pulmonary hypertension, but is currently underrecognized. [1, 2] CTEPH is a rare complication of acute... more

Prognostic interplay of kidney function with sarcopenia, anemia, disability and cognitive impairment. The GLISTEN study

10 July 2021
Author(s): Luca Soraci, Francesco Corica, Andrea Corsonello, Francesca Remelli, Pasquale Abete, Giuseppe Bellelli, Mario Bo, Antonio Cherubini, Mauro Di Bari, Marcello Maggio, Anna Maria Martone, Maria Rosaria Rizzo, Giovanna Maria Manca, Andrea P Rossi, Antonella Zambon, Stefano Volpato, Francesco Landi, GLISTEN Group Investigators

Older patients may often be affected by several chronic conditions, including chronic kidney disease (CKD), anemia, sarcopenia and neurological disorders [1–4], that are known to contribute to... more

Systemic autoimmune disorders associated with thrombotic microangiopathy: A cross-sectional analysis from the French National TMA registry: Systemic autoimmune disease-associated TMA

23 June 2021
Author(s): Nihal Martis, Matthieu Jamme, Corinne Bagnis-Isnard, Claire Pouteil-Noble, Claire Presne, Cécile Vigneau, Steven Grangé, Stéphane Burtey, Jean-Philippe Coindre, Alain Wynckel, Mohamed A Hamidou, Tarik Kanouni, Elie Azoulay, Miguel Hié, Dominique Chauveau, Agnès Veyradier, Eric Rondeau, Paul Coppo, for the French Reference Centre for Thrombotic Microangiopathies

The term thrombotic microangiopathy (TMA) defines a syndrome characterised by the association of a peripheral thrombocytopenia, a mechanical haemolytic anaemia and organ failure [1]. Thrombotic... more

Review Article

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection: One year later

19 September 2021
Author(s): Fabio Angeli, Martina Zappa, Gianpaolo Reboldi, Monica Trapasso, Claudio Cavallini, Antonio Spanevello, Paolo Verdecchia

The pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) generated much interest on the basic pathogenetic mechanisms through which SARS-CoV-2 damages diverse organ... more

Surveillance and management of colorectal dysplasia and cancer in inflammatory bowel disease: Current practice and future perspectives

1 September 2021
Author(s): Anouk M. Wijnands, Remi Mahmoud, Maurice W.M.D. Lutgens, Bas Oldenburg

Almost a century ago, Crohn and Rosenberg described the first case of ulcerative colitis (UC) complicated by colorectal carcinoma (CRC). [1] Nowadays, it is widely recognised that patients with... more

Physical activity in management of persons with obesity

21 May 2021
Author(s): Jean-Michel Oppert, Alice Bellicha, Cécile Ciangura

Physical inactivity is an important determinant of weight gain and development of obesity. Among multiple determinants of body fat gain over time, special consideration has indeed been given to... more

Mechanisms of weight regain.

16 January 2021
Author(s): Luca Busetto, Silvia Bettini, Janine Makaronidis, Carl A. Roberts, Jason C.G. Halford, Rachel L. Batterham

Obesity is a chronic progressive disease with a high tendency to recidivism. Weight regain is frequent after any attempts of voluntary weight loss [1]. Weight regain is frequently attributed to the... more


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