February 2023

30 Articles

No Section

Does etiological investigation have an impact on the outcomes of community-acquired pneumonia? – A prospective cohort study

6 December 2022
Author(s): J. Vasco Barreto, Cláudia Camila Dias, Teresa Cardoso

In clinical practice, microbial etiology of Community-Acquired Pneumonia (CAP) remains unknown in at least 60% of the cases [1]. Although there is a lack of scientific evidence that etiological... more


Pharmacological treatment of acute alcohol intoxication: More doubts than certainties

22 January 2023
Author(s): Valeria M. Petrolini, Carlo A. Locatelli

The diagnosis and treatment of acute alcohol intoxication (AAI) remains a clinical challenge [1].

Internal Medicine Flashcard

Itchy papules on the back and neck of a young woman

23 December 2022
Author(s): Takahiro Ishikawa, Minoru Takemoto, Koutaro Yokote

A 19-year-old female, healthy by nature, developed viral gastroenteritis, which cleared within a few days. A month later, she developed symptoms such as thirst, polydipsia, polyuria, and weight loss... more

Endocarditis with disseminated thromboembolisms and hypercoagulable state

16 October 2022
Author(s): Maria del Mar Gutiérrez Hernández, Alejandra Romano Cardozo, Alexander Rombauts

Ten months after radical cystectomy and adjuvant chemotherapy for an anaplastic giant cell bladder cancer (pT2N2M0), a 41-year-old woman presented with a 4-week history of intermittent claudication,... more

Internal Medicine Flashcards

Woman in a coma

16 October 2022
Author(s): Shing Ching, Chiu Sun Yue

A 49-year-old woman of unremarkable past health was found comatose in her car. Blood pressure was 130/70 mmHg, pulse 80 beats per minute. There was no circumstantial evidence of drug overdose. Urine... more

Letter to the Editor

Serological testing for SARS-CoV-2: Advancements and future challenges

26 December 2022
Author(s): Harry Alexopoulos, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos, Evangelos Terpos

It is with great interest, that we read the letter by Lippi and Plebani [1] commenting on our review article recently published in EJIM [2]. To our view both articles converge on the position that... more

‘Time out’—more transparency is required in ‘Just-in-time’ consent

29 November 2022
Author(s): Rafael Dal-Ré, Arthur L Caplan, Teck Chuan Voo

Vickers believes that a couple of statements contained in our article [1] are ‘grossly erroneous’ [2]. One is that the control group participants of Just-in-time consent “would not know that their... more

Inaccurate description of staged consent

18 November 2022
Author(s): Andrew J. Vickers

In their paper on the ethics of platform trials, Dal-Ré et al. [1] make two statements about “just-in-time” consent [2] (now more widely known as two-stage consent [3]). First, they claim that “... more

The new phase of pandemic: Are BA.2.75 and BQ.1 competitive variants? An in silico evaluation

7 November 2022
Author(s): Martina Zappa, Paolo Verdecchia, Fabio Angeli

To the Editor

Arginine in older patients with persistent atrial fibrillation: A link to endothelial dysfunction?

27 October 2022
Author(s): Stefano Fumagalli, Giulia Ricciardi, Claudia Di Serio, Giancarlo La Marca, Niccolò Marchionni

Dear Editor, atrial fibrillation (AF) is the most frequent sustained arrhythmia observed in clinical practice. Still now, thromboembolic stroke is the most relevant acute clinical complication of AF... more

Influence of vaccination and immunosuppressive treatments on the coronavirus disease 2019 outcomes in patients with systemic autoimmune diseases

20 October 2022
Author(s): Jorge Álvarez-Troncoso, Lucía López-Caballero, Ángel Robles-Marhuend, Clara Soto-Abánades, Juan José Ríos-Blanco

Systemic autoimmune diseases (SAID) are a heterogeneous group of diseases with a common etiopathogenic basis, often requiring immunosuppressive therapies (DMARD) [1]. Although case-control studies... more

Incorporation of estimated glomerular filtration rate into the GRACE score improves its prognostic performance for 10-year outcome prediction in non-ST segment elevation acute coronary syndrome treated with percutaneous coronary intervention

18 October 2022
Author(s): Piercarlo Ballo, Veronica Fibbi, Duccio Conti, Alfredo Zuppiroli, Pietro Dattolo

Current guidelines for the management of patients with non-ST elevation acute coronary syndrome (NSTE-ACS) recommend the Global Registry of Acute Coronary Events (GRACE) score for risk stratification... more

Identification of factors for persistence of AA amyloidosis in patients with Familial Mediterranean Fever

10 October 2022
Author(s): Alexandre Terré, Léa Savey, David Buob, Gilles Grateau, Sophie Georgin-Lavialle, AA Amyloidosis Study Group

Familial Mediterranean Fever (FMF) is the most common monogenic auto-inflammatory disease [1]. Patients display attacks associating recurrent fever, arthritis, serositis and skin manifestations [1].... more

Liver injury with autoimmune features after vaccination against SARS-CoV-2: The verdict is still open

5 October 2022
Author(s): Marco Ferronato, Marco Lenzi, Luigi Muratori

Dear Editor,

Young diabetics remain at higher risk of acute myocardial infarction with cannabis use disorder

3 October 2022
Author(s): Rupak Desai, Akhil Jain, Bhavin A Patel, Ashish Sadolikar, Thomas Alukal

Diabetes mellitus (DM) is a known risk factor for cardiovascular complications. Diabetic patients have higher rates of morbidity, mortality, and reinfarction following myocardial infarction than non-... more

‘Paperdemic’ during the COVID-19 pandemic

2 October 2022
Author(s): Yang Yang, Na Zhao, Ting Ma, Ze Yuan, Cheng Deng

The 2019 novel coronavirus disease (COVID-19) has spread globally with substantial health and socioeconomic impacts. The scientific community has timely responded to this global crisis by launching... more

Can we use platelet-to-lymphocyte ratio (PLR) to differentiate JAK2-unmutated erythrocytosis from polycythemia vera?

29 September 2022
Author(s): Ivan Krečak, Marko Lucijanić

with great interest we have read the recent article by Ernest et al. [1] reporting distinctive clinical and laboratory features of patients with Janus Kinase 2 (JAK2)-unmutated erythrocytosis.... more

Ibrutinib use and adverse cardiovascular outcomes: A United States federated electronic medical records analysis

24 September 2022
Author(s): David G. Gent, José M. Rivera-Caravaca, Rebecca Dobson, David J. Wright, Gregory Y.H. Lip, Liverpool Centre for Cardiovascular Science

Ibrutinib, an irreversible inhibitor of Bruton's Tyrosine Kinase (BTK), forms the standard of care for certain B cell malignancies including chronic lymphocytic leukaemia (CLL). Atrial fibrillation (... more

Original Article

Prognostic implication of coronary slow flow assessed by cTFC in patients with myocardial infarction with Non-obstructive coronary arteries

2 December 2022
Author(s): Redhwan M. Mareai, Abdul-Quddus Mohammed, Hengbin Zhang, Lu Liu, Wen Zhang, Ayman A. Mohammed, Guoqing Yin, Xian Lv, Yawei Xu, Fuad A. Abdu, Wenliang Che

Ischemic heart disease, especially myocardial infarction (MI), is an expanding threat to public health and a leading cause of premature disability and mortality [1,2]. A significant number of... more

Patients treated with rituximab are poorly screened for hepatitis B infection: Data from a low-incidence country

30 November 2022
Author(s): Sylvia M Brakenhoff, Roos Hoekstra, Pieter Honkoop, Robert Roomer, Jan G den Hollander, Geert Bezemer, Robert J de Knegt, Milan J Sonneveld, Robert A de Man

Hepatitis B virus infection (HBV) is considered a global health threat as it is associated with liver decompensation, liver cirrhosis and primary liver cancer [1]. Worldwide, approximately 269... more

Delaying clinical events among patients with non-valvular atrial fibrillation treated with oral anticoagulants: Insights from the ARISTOPHANES study

28 November 2022
Author(s): Steven Deitelzweig, Allison Keshishian, Amiee Kang, Aaron Jenkins, Nipun Atreja, Patricia Schuler, Jenny Jiang, Huseyin Yuce, Xiaoxi Sun, Gregory Y.H. Lip

Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States, with prevalence currently estimated at 6 million which is projected to increase to 12 million by 2030, in line... more

Similarities and differences between Gaucher disease and acid sphingomyelinase deficiency: An algorithm to support the diagnosis

26 November 2022
Author(s): Maria Domenica Cappellini, Irene Motta, Antonio Barbato, Gaetano Giuffrida, Raffaele Manna, Francesca Carubbi, Fiorina Giona

Lysosomal storage disorders (LSDs) are a group of inborn errors of metabolism resulting from defects in proteins crucial for lysosomal function [1]. Phenotypic expression is extremely variable and... more

Systemic treatment in sarcoidosis: Experience over two decades

26 November 2022
Author(s): Raúl Fernández-Ramón, Jorge J. Gaitán-Valdizán, Iñigo González-Mazón, Lara Sánchez-Bilbao, José L. Martín-Varillas, David Martínez-López, Rosalía Demetrio-Pablo, M.Carmen González-Vela, Iván Ferraz-Amaro, Santos Castañeda, Miguel A. González-Gay, Ricardo Blanco

Sarcoidosis is a multisystemic disease of unknown etiology characterized by the presence of non-caseating granulomas in various organs, especially in lungs and mediastinum-hilar lymph nodes. The... more

The impact of preconception counselling on maternal and fetal outcomes in women with chronic medical conditions: A systematic review

23 November 2022
Author(s): Melanie Nana, Madeleine Trowsdale Stannard, Catherine Nelson-Piercy, Catherine Williamson

Preconception care (PCC) is defined by the World Health Organisation as a set of interventions that are to be provided, before pregnancy, to promote the health and well-being of women and couples, as... more

Deep vein thrombosis symptoms and 30-day mortality in acute pulmonary embolism

16 November 2022
Author(s): Álvaro Dubois-Silva, Cristina Barbagelata-López, Patricia Piñeiro-Parga, Luciano López-Jiménez, Antoni Riera-Mestre, Sebastian Schellong, Judith Catella, Marijan Bosevski, Mireia Roca Toledo, Manuel Monreal, the RIETE Investigators

In patients with acute symptomatic pulmonary embolism (PE), the presence of concomitant lower-limb deep vein thrombosis (DVT) has been identified as an independent predictor of death [1–5]. The... more

Hypertension and mortality in SARS-COV-2 infection: A meta-analysis of observational studies after 2 years of pandemic

16 November 2022
Author(s): Lanfranco D'Elia, Alfonso Giaquinto, Aquilino Flavio Zarrella, Domenico Rendina, Paola Iaccarino Idelson, Pasquale Strazzullo, Ferruccio Galletti

Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been affecting millions of people around the world since December 2019 [1].

Review Article

Current approaches for the diagnosis and management of immune thrombocytopenia

21 November 2022
Author(s): Anat Gafter-Gvili

Immune thrombocytopenia (ITP), previously called idiopathic thrombocytopenic purpura, is an acquired autoimmune disorder characterized by the destruction of platelets and megakaryocytes, resulting in... more

Autoimmune serology testing in clinical practice: An updated roadmap for the diagnosis of autoimmune hepatitis

16 November 2022
Author(s): George N. Dalekos, Nikolaos K. Gatselis

The diagnosis of autoimmune hepatitis (AIH) is based on a combination of clinical, laboratory and histological findings in patients with unexplained acute or chronic hepatitis [1–3]. The disease is... more

Identification and management of acute alcohol intoxication

16 August 2022
Author(s): Antonio Mirijello, Luisa Sestito, Mariangela Antonelli, Antonio Gasbarrini, Giovanni Addolorato

Alcohol is the oldest and most common psychoactive and addictive substance used in our society: it has been estimated that about 90% of people consume alcohol at some stage in their lives and up to... more


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