October 2019

13 Articles

No Section

Fifty years of research on antithrombotic therapy: Achievements and disappointments

31 October 2019
Author(s): Jack Hirsh, John W Eikelboom, Noel C Chan

The achievements with antithrombotic therapy over the past 50 years have been monumental and the disappointments relatively few. In this review, we will discuss, chronologically, the major... more

Overlooked cases of HIV infection: An Italian tale of missed diagnostic opportunities

18 October 2019
Author(s): Lorena van den Bogaart, Alice Ranzani, Letizia Oreni, Andrea Giacomelli, Mario Corbellino, Stefano Rusconi, Massimo Galli, Spinello Antinori, Anna Lisa Ridolfo

Major advances in antiretroviral therapy (ART) over the last 20 years have dramatically changed the natural history of HIV infection, leading to the durable suppression of viral replication and... more


Short length of hospitalization in patients with acute heart failure entails a high risk of readmission: True or false? Insights from the LOHRCA study

31 October 2019
Author(s): Pedro Moliner, Josep Comin-Colet

Heart failure (HF) is a chronic disease with devastating consequences in terms of mortality, morbidity, health-related quality of life and healthcare costs [1]. Furthermore, several factors... more

Frailty and delirium: Unveiling the hidden vulnerability of older hospitalized patients

24 October 2019
Author(s): M. Fedecostante, A. Cherubini

Frailty and delirium are two of the most problematic issues in the management of older hospitalized patients. The term frailty, from the Latin “fragilis” meaning “easily broken”, refers to a... more

Internal Medicine Flashcard

Ear pain, vesicles and facial palsy

29 October 2019
Author(s): Edouard Flamarion, Justine Zini, Amélie Passeron

Case presentation - A 35-year-old previously healthy man presented to the emergency department with a left-sided facial palsy (Fig 1. Panel A). Four days before, he complained of left ear pain with... more

Letter to the Editor

Worldwide epidemiology of alcohol and drugs abuse

31 October 2019
Author(s): Camilla Mattiuzzi, Giuseppe Lippi

Although there is widespread perception that the burden of alcohol and drugs abuse is relatively common around the world [1], no recent epidemiologic information has been published in support of this... more

Prevalence and risk factors associated with fatal adverse drug reactions among patients admitted at a Spanish teaching hospital

17 October 2019
Author(s): Alfredo Jose Pardo-Cabello, Juan de Dios Luna, Francisco Javier Gómez Jiménez, Esperanza Del Pozo, Emilio Puche Cañas

The toxicity of pharmacological treatments remains a major clinical challenge with important health implications. Best estimates from the medical and scientific literature suggest that 0.12%–0.22% of... more

Frailty and subsequent mortality in the elderly: A risk assessment

9 October 2019
Author(s): Tomoyuki Kawada

I read with great interest the paper by Zucchelli et al. [1], which is a cohort study to determine the effect of frailty on mortality in adults aged 60+ without multi-morbidity. Within the first 5 ... more

Original Article

Benefits of statins in chronic obstructive pulmonary disease patients with pulmonary hypertension: A meta-analysis

31 October 2019
Author(s): Guizuo Wang, Wenli Shang, Yajuan Ren, Sining Liu, Xiaoping Ren, Shenghong Wei, Dong Han

Chronic obstructive pulmonary disease (COPD) with its comorbidities is one of the five major causes of death worldwide [1]. Pulmonary hypertension (PH) is a serious condition classified into five... more

Prevalence of medication transfer errors in nephrology patients and potential risk factors

9 October 2019
Author(s): M.M. Ebbens, H. Errami, D.J.A.R. Moes, P.M.L.A. van den Bemt, P.J.M. van der Boog, K.B. Gombert-Handoko

Medication reconciliation in transitions of care can prevent medication transfer errors (MTE). MTE can cause patient harm. Since performing medication reconciliation for every patient is not always... more

Easy prognostic assessment of concomitant organ failure in critically ill patients undergoing mechanical ventilation

9 October 2019
Author(s): Bernhard Wernly, Fernando Frutos-Vivar, Oscar Peñuelas, Konstantinos Raymondos, Alfonso Muriel, Bin Du, Arnaud W. Thille, Fernando Ríos, Marco González, Lorenzo del-Sorbo, Maria del Carmen Marín, Bruno Valle Pinheiro, Marco Antonio Soares, Nicolas Nin, Salvatore M. Maggiore, Andrew Bersten, Malte Kelm, Pravin Amin, Nahit Cakar, Michael Lichtenauer, Gee Young Suh, Fekri Abroug, Manuel Jibaja, Dimitros Matamis, Amine Ali Zeggwagh, Yuda Sutherasan, Antonio Anzueto, Andrés Esteban, Christian Jung

Acute respiratory distress syndrome (ARDS) is a life-threatening disease. We evaluated the prognostic utility of Model for End-stage Liver Disease excluding INR (MELD-XI) score for predicting... more

Review Article

Never enough recommended. Beyond the AHA/ACC guideline on lifestyle and behavior for cardiovascular prevention

31 October 2019
Author(s): Claudio Cimminiello

“An apple a day keeps the doctor away”. But the saying seems true even once the doctor already did his job. The recent AHA/ACC guidelins on the primary prevention of cardiovascular diseases [1] and... more

Evaluation, risk stratification and management of hypertensive patients in the perioperative period

9 October 2019
Author(s): Maria Koutsaki, Dimitrios Patoulias, Pavlos Tsinivizov, Michael Doumas, Manolis Kallistratos, Costas Thomopoulos, Leonidas Poulimenos, Giancarlo Agnelli, Giuseppe Mancia, Athanasios Manolis

Uncontrolled hypertension represents an important cause for postponing a non-cardiac surgery. Perioperative management of hypertensive patients should focus on cardiovascular risk stratification,... more


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