April 2021

27 Articles

No Section

Inhaled long-acting muscarinic antagonists in asthma – A narrative review

6 February 2021
Author(s): Alberto Papi, Leonardo M Fabbri, Huib A.M. Kerstjens, Paola Rogliani, Henrik Watz, Dave Singh

The efficacy of muscarinic antagonists in asthma has been known since the early 1800s when inhalation of smoke from burning Datura stramonium leaves and roots became widespread in Britain as a... more


Postoperative atrial fibrillation after non-cardiac surgery: How important is it and what do we do about it?

3 February 2021
Author(s): Michael Ke Wang, James Douketis

Postoperative atrial fibrillation (POAF), defined as the occurrence of new-onset AF in the perioperative setting, is a common complication occurring in up to 3% of patients undergoing non-... more

Proton Pump Inhibitor (PPI) co-therapy and gastrointestinal bleeding with antithrombotic drugs: a step forward but not enough

21 January 2021
Author(s): Angel Lanas

Nonvariceal gastrointestinal (GI) bleeding is common and one of the most frequent medical events which determine hospitalizations worldwide. Death rates (5-12%) in patients with GI bleeding are... more

Internal Medicine Flashcard

A forgotten disease in Japan

31 January 2021
Author(s): Hiroki Matsuura, Kentaro Deguchi

A 67-year-old woman with acute onset of fever, disorientation, and confusion was transferred to our emergency department. Physical findings revealed neck stiffness, left dominant tremulous arms with... more

A man with arthralgias and skin lesions

28 January 2021
Author(s): Fabrizio Elia, Giorgia Protti, Franco Aprà

A healthy 43-year-old man presented to the Emergency Department with a one-week history of fever, low back pain and arthralgias mainly localized in the right knee. Physical examination revealed... more

Letter to the Editor

Mid-day sleep and blood pressure in patients with arterial hypertension. Author's reply

5 January 2021
Author(s): MS Kallistratos, LE Poulimenos, AJ Manolis

We thank Dr Kawada for his comments on our study [1]. He raised some concerns regarding the effect of mid-day sleep on alertness and performance as well as health outcomes. He based his concerns on... more

Proprotein Convertase Subtilisin-Kexin Type 9 inhibitors and stroke prevention: A meta-analysis

5 January 2021
Author(s): Dimitrios Sagris, George Ntaios, Georgios Georgiopoulos, Konstantinos Pateras, Haralampos Milionis

Dear Editor, over the last decades lipid-modifying strategies made a pivotal change in cardiovascular prevention especially in patients with previous coronary artery disease or ischemic stroke. In... more

Associating enterococcal endocarditis and colorectal neoplasia: is colonoscopy mandatory? – Authors’ reply

31 December 2020
Author(s): Lorenzo Bertolino, Maria Paola Ursi, Rosa Zampino, Emanuele Durante-Mangoni

We are glad to share with Corredoira and colleagues the interest for our recently published work regarding the relationship between Enteroccocus spp infective endocarditis (EIE) and colorectal... more

NEWS2 is a valuable tool for appropriate clinical management of COVID-19 patients

21 December 2020
Author(s): Marta Rigoni, Emanuele Torri, Giandomenico Nollo, Livia Delle Donne, Susanna Cozzio

Coronavirus disease 2019 (COVID-19) is a severe acute respiratory infection caused by an emergent coronavirus, SARS-CoV-2, recognized in Wuhan (China) in December 2019. The World Health Organization... more

Prognostic Implications of Residual Pleural Effusions at Discharge in Patients with Acute Decompensated Heart Failure

1 December 2020
Author(s): Hidenori Yaku, Yuta Seko, Takao Kato, Takeshi Morimoto, Takeshi Kimura

Pleural effusion, which is included as one of the Framingham minor diagnostic criteria for heart failure (HF), is one of the common signs reflecting body fluid retention and can be quickly and... more

Angiotensin-converting enzyme inhibitors versus angiotensin II receptor blockers for renal outcomes and mortality in diabetic kidney disease

26 November 2020
Author(s): Shimin Jiang, Jinying Fang, Tianyu Yu, Wenge Li

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Inhibition of intrarenal renin-angiotensin system (RAS) with angiotensin-converting enzyme inhibitors (... more

Associating enterococcal endocarditis and colorectal neoplasia: is colonoscopy mandatory?

20 November 2020
Author(s): J. Corredoira, E. Romay, J.M. Pericàs, J.M. Miró

Dear Editor:

Sodium fluctuation, a novel single parameter to predict hospital mortality

19 November 2020
Author(s): Siyu Liang, Shi Chen, Yuelun Zhang, Huijuan Zhu, Hui Pan

Dysnatremia is the most common electrolyte disorder in hospitalized patients [1]. Dysnatremia is generally classified as hyponatremia (145mmol/L). Many studies showed that hypernatremia and... more

Risk of infectious events in acute myocardial infarction patients treated with ticagrelor or clopidogrel

13 November 2020
Author(s): Cheng-Han Lee, Hui-Wen Lin, Nan-Yao Lee, Sheng-Hsiang Lin, Yi-Heng Li

Ticagrelor is an oral direct-acting antiplatelet agent that inhibits P2Y12 receptor activation. The PLATO study showed that ticagrelor significantly reduced the composite outcome of vascular death,... more

Original Article

The Diagnosis of Acute Myocarditis in Emergency (DAME) score: improving diagnostics within the emergency department.

24 January 2021
Author(s): Pietro Scicchitano, Lorenzo Grazioli Gauthier, Carlo D'Agostino, Pasquale Caldarola, Biagio Solarino, Francesco Massari, Francesco Chiarella, Gianfranco Sinagra, Fabio Manca, Marco Matteo Ciccone

Myocarditis is defined as an inflammatory cardiac muscular disease. The etiology is extremely heterogeneous, the causes varying from infective (bacterial, viral, etc) to non-infective (drugs,... more

Validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in Internal Medicine wards; a prospective, multicenter study

12 January 2021
Author(s): Alberto Fortini, Antonio Faraone, Simone Meini, Michael Bettucchi, Benedetta Longo, Beatrice Valoriani, Silvia Forni, Italian Federation of Hospital Internists (FADOI) - Sepsis Collaboration Group of the Tuscany Region

Few data are available on the validity of “Sepsis-3” criteria in identifying patients with sepsis in internal medicine wards (IMWs). Real-life data about this topic and on the prevalence of sepsis in... more

Alcoholic liver disease and autoimmune hepatitis: Sometimes a closer look under the surface is needed

12 January 2021
Author(s): Eirini I. Rigopoulou, Nikolaos Gatselis, Pinelopi Arvaniti, George K. Koukoulis, George N. Dalekos

Differential diagnosis of autoimmune hepatitis (AIH) incorporates various liver diseases, including alcoholic liver disease (ALD). We report on clinical, laboratory and outcome characteristics of AIH... more

Long-term outcomes of postoperative atrial fibrillation following non cardiac surgery: A systematic review and metanalysis

2 January 2021
Author(s): Alessandro Albini, Vincenzo Livio Malavasi, Marco Vitolo, Jacopo Francesco Imberti, Marco Marietta, Gregory Y.H. Lip, Giuseppe Boriani

New-onset atrial fibrillation (AF) in non-cardiac postoperative setting is common and is associated with a high risk of in-hospital mortality and morbidity. The long-term risks of stroke, mortality... more

Lung ultrasonography: A prognostic tool in non-ICU hospitalized patients with COVID-19 pneumonia

2 January 2021
Author(s): Francesco Casella, Marco Barchiesi, Federica Leidi, Giulia Russo, Giovanni Casazza, Giulia Valerio, Daniela Torzillo, Elisa Ceriani, Marta Del Medico, Anna Maria Brambilla, Maria Alessandra Mazziotti, Chiara Cogliati

From February to March 2020, Italy became the most affected country worldwide by coronavirus disease (COVID-19). Our healthcare system was put under enormous pressure, especially in Lombardia which... more

Prevalence and impact on outcome of sodium and potassium disorders in patients with community-acquired pneumonia: A retrospective analysis

24 December 2020
Author(s): Svenja Ravioli, Rebecca Gygli, Georg-Christian Funk, Aristomenis Exadaktylos, Gregor Lindner

Disorders of serum sodium and potassium are frequently encountered in hospitalized patients and patients presenting to the emergency department (ED) [1, 2].

Cardiac involvement in eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): Prospective evaluation at a tertiary referral centre

22 December 2020
Author(s): Mattia Zampieri, Giacomo Emmi, Matteo Beltrami, Carlo Fumagalli, Maria Letizia Urban, Lorenzo-Lupo Dei, Alberto Marchi, Martina Berteotti, Alessia Tomberli, Katia Baldini, Alessandra Bettiol, Silvia Pradella, Elena Silvestri, Niccolò Marchionni, Augusto Vaglio, Iacopo Olivotto, Domenico Prisco

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis. Cardiac specific involvement (CSI) is caused by coronary artery vasculitis, but also by myocardial eosinophilic... more

The Atrial fibrillation Better Care (ABC) pathway and cardiac complications in atrial fibrillation: a potential sex-based difference. The ATHERO-AF study

21 December 2020
Author(s): Daniele Pastori, Danilo Menichelli, Francesco Violi, Pasquale Pignatelli, Gregory Y H Lip, the ATHERO-AF study group

An integrated care approach is recommended to optimize management of patients with atrial fibrillation (AF). The impact of the Atrial fibrillation Better Care (ABC) pathway on major adverse cardiac... more

Home FIRsT: interdisciplinary geriatric assessment and disposition outcomes in the Emergency Department

24 November 2020
Author(s): Íde O'Shaughnessy, Roman Romero-Ortuno, Lucinda Edge, Aoife Dillon, Sinéad Flynn, Robert Briggs, Darragh Shields, Geraldine McMahon, Arthur Hennessy, Una Kennedy, Paul Staunton, Rosa McNamara, Suzanne Timmons, Frances Horgan, Conal Cunningham

With population ageing worldwide, the numbers of older people attending Emergency Departments (ED) continue to increase, which may lead to adverse operational and patient outcomes. [1] Older people... more

Serum levels of C-terminal FGF23 (cFGF23) are associated with 1-year-mortality in patients undergoing transcatheter aortic valve replacement (TAVR)

13 November 2020
Author(s): Moritz Mirna, Alexander Lauten, Peter Jirak, Richard Rezar, Bernhard Wernly, Vera Paar, Thomas K. Felder, Uta C. Hoppe, Lukas J. Motloch, Christian Jung, Brunilda Alushi, Michael Lichtenauer, Hermann Salmhofer

The family of fibroblast growth factors (FGFs) was discovered in 1975 [1] and has since been investigated in numerous scientific studies. The FGFs comprise a group of 22 small polypeptides (... more

Prevalence, risk factors and proteomic bioprofiles associated with heart failure in rheumatoid arthritis: The RA-HF study

7 November 2020
Author(s): Maria Betânia Ferreira, Tomás Fonseca, Rita Costa, António Marinhoc, Henrique Cyrne Carvalho, José Carlos Oliveira, Faiez Zannad, Patrick Rossignol, Jacques-Eric Gottenberg, Francisca A. Saraiva, Patrícia Rodrigues, António S. Barros, João Pedro Ferreira

Rheumatoid Arthritis (RA) is a systemic chronic and progressive inflammatory disease, characterized by persistent synovitis and joint erosion [1]. It affects around 1% of the general population and... more

Review Article

Gastroprotection in patients on antiplatelet and/or anticoagulant therapy: a position paper of National Association of Hospital Cardiologists (ANMCO) and the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO)

2 December 2020
Author(s): Maurizio Giuseppe Abrignani, Luigi Gatta, Domenico Gabrielli, Giuseppe Milazzo, Vincenzo De Francesco, Leonardo De Luca, Maura Francese, Massimo Imazio, Elisabetta Riccio, Roberta Rossini, Fortunato Scotto di Uccio, Marco Soncini, Angelo Zullo, Furio Colivicchi, Andrea Di Lenarda, Michele Massimo Gulizia, Fabio Monica

Aspirin and P2Y12 receptor antagonists are widely used across the spectrum of cardiovascular and cerebrovascular diseases. Gastrointestinal complications, including ulcer and bleeding, are relatively... more


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